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Published on
September 17, 2026
The past, present and future of de novo protein design
RFdiffusion anfinsens-hypothesis PDB activation-maximization Chroma escherichia-coli masked-language-models 3D-crystal 1D-fibre 2D-lattice 9OP9 NCAA beta-barrel Top7 TIM-barrel protein-language-models rosetta nanopore macrocycle oligoamide BindCraft ProGen PXDesign affinity TNF scFv VHH CDR HELM-GPT RFpeptides IDR PepPrCLIP affinity-handle beta-catenin SS18-SSX1 beta-amyloid tau-protein glycoproteins oligomerization FGF endocytosis transcytosis EndoTags digoxigenin methotrexate CID kemp-elimination retro-aldol luciferase PLACER serine CRISPR-Cas zinc-fingers
Research notes on The past, present and future of de novo protein design.
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The past, present and future of de novo protein design