- Published on
De novo design of allosterically controlled enzymes
- Authors
- Name
- Vishal V
- @VishalVignesh_
Notes
Abstract
cellular processes from signaling to metabolic control (1)
denoising diffusion models enable the design of compact de novo enzymes whose activity can be allosterically activated or repressed by designed protein effectors (1)
Intro
Cell signaling cascades 1, metabolic pathways2,3, and motor proteins 4,5 often rely on coupling between enzymatic activity and protein-ligand binding at sites distal to the active site (1)
Distal as in place elsewhere from the active site.